CUBIC - K

Product

Product: Product

Real-time Monitoring System

Due to the significant impact of solution concentration and environmental conditions on biochemical reactions, continuous monitoring is essential.
Traditional monitoring methods, such as offline sampling, often lead to inconsistencies and are prone to measurement errors due to exposure to external conditions.
Furthermore, these methods require extensive time for preprocessing and analysis.

Cubic-K offers real-time automated monitoring, high-sensitivity detection, and user-friendly solutions.
By integrating probe electrodes within the reactor, preprocessing steps
can be eliminated, enabling real-time detection through Surface-Enhanced Raman Scattering (SERS).
The presence of metallic nanostructures within the probe electrodes ensures high-sensitivity detection,
while a probe guard is equipped for bubble/particle removal and nanostructure protection.
Additionally, real-time monitoring is facilitated by AI-based signal analysis and output software.

Prototype

Our system allows for real-time measurement of desired substance concentrations from the culture medium during bioreactor processes.
With the prototype, effective removal of gaseous substances and particulates within the reactor ensures stable signal acquisition free from noise.
Utilizing Raman signal detection, our technology enables high-sensitivity detection of target substances within the reactor.
This capability allows for the maintenance of optimal culture conditions and accurate prediction of product concentrations.

Customized Substance Detection

Nanoparticle Design Tailored to Target Substances
High-sensitivity Detection

Capable of Detecting Concentrations Below 10 µm
Real-time Automated Monitoring

Detection Results Monitored Within 3 Seconds

Publications and Patents

"Direct and precise determination of volumetric mass transfer coefficient of carbon monoxide for miniaturized
gas-liquid reactors via sensitive probing of raman transitions.“
Chemical Engineering Journal (2022).
"Inner-membrane-bound gold nanoparticles as efficient electron transfer mediators for enhanced
mitochondrial electron transport chain activity.“
Nano Letters (2022).
“Effect of Mass Transport by Convective Flow on the Distribution of Dissolved Carbon Monoxide in a Stirred Tank.“
Applied Sciences (2022).
"Generalized On-demand Production of Nanoparticle Monolayers on Arbitrary Solid Surfaces via
Capillarity-Mediated Inverse Transfer.“
Nano Letters (2019).
"Plasmonic bacteria on a nanoporous mirror via hydrodynamic trapping for rapid identification of waterborne
pathogens.“
Light: Science & Applications (2018).
"Three-dimensional Assembly of Metal Nanoparticles at Oleic Acid/water Interface via Their Autonomous and
Rapid Interfacial Locomotion.“
Advanced Materials Interfaces (2018).
Method for Fabricating Large-scale Plasmonic Substrate Having High-density Close-packed
Gold Nanoparticles Assembled on Metal Film and Plasmonic Substrate Fabricated Thereby (1020180024005).
Apparatus for Predicting Dissolved Gas Concentration in Aqueous Solution Based on Raman
Spectral Signal and Method Therefor (1020200123589).
Method for Fabricating Large-scale Plasmonic Substrate Having High-density Close-packed
Gold Nanoparticles Assembled on Metal Film and Plasmonic Substrate Fabricated Thereby (1020180024005).
Apparatus for Predicting Shape of Metal Nanoparticles in the Heat Treatment Process, Method for Predicting Thereof (1020200124066).
Apparatus and Method for On-line Monitoring of Dissolved C1 Gas in Non-equilibrium State via Surface-enhanced Raman Spectroscopy Using Bimetallic Nanostructure (1020180127924).
Apparatus for Predicting Matter Species and Matter Concentration on Aqueous Solution, Method for Predicting Thereof (1020180152035).
Apparatus and Method for On-line Monitoring of Metabolic Products from Bioconversion via Surface Enhanced Raman Spectroscopy using Electrostatic Interaction of Metallic Nanostructure (102018012792).
Carousel for the Movement of Containers in Inspection Machines (1020230004843, PCT/KR2023/007412).
Bubble Separating Apparatus for Spectrometer Bioreactor and Bioreactor Including the Same (1020230072362).